Arsenal will travel to Greece to seek revenge on Olympiakos who ousted them from the tournament last season in the round of 32 while Manchester United is set to face Italian giants AC Milan in the last 16 of the Europa League.
The Greek champions play their home matches at the Karaiskakis Stadium, the venue for Arsenal’s dramatic victory over Benfica in the last 32 of the competition on Thursday.
Manchester United, however, will play host in the first leg against Milan, which will see their former striker Zlatan Ibrahimovic return to Old Trafford.
Another English side who progressed to the round of 16, Tottenham Hotspur, will face Dinamo Zagreb.
Spurs won the UEFA Cup – the previous incarnation of the Europa League – in 1972 and 1984, while their manager Jose Mourinho lifted the trophy with Porto in 2003 and Manchester United in 2017.
Elsewhere in the draw, former Arsenal manager Unai Emery – the most successful manager in the history of the Europa League – will see his current side Villarreal take on Dynamo Kiev.
Red hot Italian side AS Roma will face 2009 UEFA Cup winners Shakhtar Donetsk, while the winners of the competition in 1992, Ajax will face Swiss side Young Boys.
Granada, another team flying the Spanish flag in the competition will continue their impressive campaign against Norwegian side Molde. The Spanish club is currently enjoying their first season in European competition and stunned Italian giants Napoli in the previous round.
The first legs of the last-16 ties will take place on March 11 and the return legs a week later.
The quarter-final and semi-final draw will then be held on March 19 in Nyon, Switzerland.
Europa League last-16 draw
- Ajax vs Young Boys
- Dynamo Kiev vs Villarreal
- Roma vs Shakhtar Donetsk
- Olympiakos vs Arsenal
- Dinamo Zagreb vs Tottenham
- Manchester United vs AC Milan
- Slavia Prague vs Rangers
- Granada vs Molde